Text-based search: First, enter your target name, compound name or ID. Then, select which dataset to search.
Structure-based search: First, draw your structure, input SMILES or upload a MOL/SDF file. Then, choose the search type. In the similarity search, the bit vector Morgan fingerprint, an FCFP-like fingerprint, is utilized to characterize the chemical features of a molecule. Finally, select which dataset to search.
The ternary complex structure section displays the PROTAC-mediated ternary complex. For the PROTACs with good degradation capacity but no crystal structures, we also provide the predicted ternary complex models using our PROTAC-Model method (J. Med. Chem. 2021, 64, 21, 16271-16281).
PROTACs based on this warhead or E3 ligand are also displayed on the warhead/E3 ligand page. Taking the warhead page as an example, the features are as follows.