PROTAC-DB is the first web-accessible database dedicated to proteolysis-targeting chimeras (PROTACs). Users can search compounds through target, chemical structure, compound name, SMILES and ID. The chemical structures, biological activities, physiochemical properties and pharmacokinetic parameters of these compounds were manually extracted from the literature or calculated by some programs. In addition, considering the importance and limited number of crystal structures of ternary complex, we also provide the predicted ternary complex models for PROTACs with good degradation capacity using our PROTAC-Model method. We will constantly add new data and improve the usability of the interface. The latest version of PROTAC-DB was released on 2025-02-17.
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