protacdb Server

PROTAC-DB is a comprehensive web-accessible knowledgebase for targeted protein degradation. The database integrates diverse degradation modalities, including PROTACs, molecular glues (MGs) and X-functional TArgeting Chimeras (XTACs), together with their associated targets, biological activities, molecular properties and literature evidence. Users can search and explore degradation-related knowledge through targets, compound names, chemical structures, SMILES, IDs and natural language queries. In addition to curated database records, PROTAC-DB provides predicted ternary complex models generated by the PROTAC-Model method and an LLM-powered retrieval system that unifies structured database information with unstructured literature knowledge. PROTAC-DB is freely accessible and continuously updated to facilitate degrader discovery and the rational design of next-generation targeted degradation therapeutics. The latest version of PROTAC-DB was released on 2026-06-09. Learn more >