Nav1.9

Target Information
VGSC-DB Target ID NAT009
Name Sodium channel protein type 11 subunit alpha
Synonyms
  • Peripheral nerve sodium channel 5
  • Sensory neuron sodium channel 2
  • Sodium channel protein type XI subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.9
  • hNaN
Description This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Organism Human, Mouse, Rat
PDB ID None
UniProt Q9UI33, Q9R053, O88457
Structure
SOURCE IDENTIFIER METHOD RESOLUTION ORGANISMS DOWNLOAD
AlphaFold2 AF-Q9UI33-F1 Predicted Human
AlphaFold2 AF-O88457-F1 Predicted Rat
AlphaFold2 AF-Q9R053-F1 Predicted Mouse
Compounds
VGSC-DB ID Sructure PubChem CID Molecular Formula IC50/EC50* (nM) Binding Site Organism Article DOI