Nav1.7

Target Information
VGSC-DB Target ID NAT007
Name Sodium channel protein type 9 subunit alpha
Synonyms
  • Neuroendocrine sodium channel
  • Peripheral sodium channel 1
  • Sodium channel protein type IX subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.7
Description Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na+ channel isoform.Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Organism Human, Mouse, Rat
PDB ID 6J8G, 6J8H, 6J8I, 6J8J
UniProt Q15858, Q62205, O08562
Structure
SOURCE IDENTIFIER METHOD RESOLUTION ORGANISMS DOWNLOAD
PDB 6J8G EM 3.20Å Homo sapiens
PDB 6J8H EM 3.20Å Homo sapiens
PDB 6J8I EM 3.20Å Homo sapiens
PDB 6J8J EM 3.20Å Homo sapiens
AlphaFold2 AF-Q15858-F1 Predicted Human
AlphaFold2 AF-O08562-F1 Predicted Rat
AlphaFold2 AF-Q62205-F1 Predicted Mouse
Compounds
VGSC-DB ID Sructure PubChem CID Molecular Formula IC50/EC50* (nM) Binding Site Organism Article DOI