Nav1.7
VGSC-DB Target ID | NAT007 |
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Name | Sodium channel protein type 9 subunit alpha |
Synonyms |
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Description | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na+ channel isoform.Plays a role in pain mechanisms, especially in the development of inflammatory pain. |
Organism | Human, Mouse, Rat |
PDB ID | 6J8G, 6J8H, 6J8I, 6J8J |
UniProt | Q15858, Q62205, O08562 |
Compounds |
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VGSC-DB ID | Sructure | PubChem CID | Molecular Formula | IC50/EC50* (nM) | Binding Site | Organism | Article DOI |
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