Nav1.4

Target Information
VGSC-DB Target ID NAT004
Name Sodium channel protein type 4 subunit alpha
Synonyms
  • Sodium channel protein skeletal muscle subunit alpha
  • Sodium channel protein type IV subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.4
Description Pore-forming subunit of a voltage-gated sodium channel complex through which Na+ ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states.Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K+ levels.
Organism Human, Mouse, Rat
PDB ID 6AGF
UniProt P35499, Q9ER60, P15390
Structure
SOURCE IDENTIFIER METHOD RESOLUTION ORGANISMS DOWNLOAD
PDB 6AGF EM 3.20Å Homo sapiens
AlphaFold2 AF-P15390-F1 Predicted Rat
AlphaFold2 AF-P35499-F1 Predicted Human
AlphaFold2 AF-Q9ER60-F1 Predicted Mouse
Compounds
VGSC-DB ID Sructure PubChem CID Molecular Formula IC50/EC50* (nM) Binding Site Organism Article DOI