Nav1.3

Target Information
VGSC-DB Target ID NAT003
Name Sodium channel protein type 3 subunit alpha
Synonyms
  • Sodium channel protein brain III subunit alpha
  • Sodium channel protein type III subunit alpha
  • Voltage-gated sodium channel subtype III
  • Voltage-gated sodium channel subunit alpha Nav1.3
Description Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient (By similarity).
Organism Human
PDB ID 7W7F, 7W77
UniProt Q9NY46
Structure
SOURCE IDENTIFIER METHOD RESOLUTION ORGANISMS DOWNLOAD
PDB 7W7F EM 3.35Å Homo sapiens
PDB 7W77 EM 3.30Å Homo sapiens
AlphaFold2 AF-Q9NY46-F1 Predicted Human
Compounds
VGSC-DB ID Sructure PubChem CID Molecular Formula IC50/EC50* (nM) Binding Site Organism Article DOI
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