- Molecular NameCysteamine
- SynonymN/A
- Weight78.157
- Drugbank_IDDB00847
- ACS_NO60-23-1
- Show 2D model
- LogP (experiment)-0.196
- LogP (predicted, AB/LogP v2.0)-0.02
- pkaN/A
- LogD (pH=7, predicted)-2.62
- Solubility (experiment)Soluble
- LogS (predicted, ACD/Labs)(ph=7)1.11
- LogSw (predicted, AB/LogsW2.0)25.33
- Sw (mg/ml) (predicted, ACD/Labs)233.19
- No.of HBond Donors2
- No.of HBond Acceptors1
- No.of Rotatable Bonds1
- TPSA64.82
- StatusFDA approved
- AdministrationN/A
- PharmacologyRadiation-Protective Agents
- Absorption_value0.0
- Absorption (description)N/A
- Caco_20.0
- Bioavailability0.0
- Protein binding52.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmCysteamine is an aminothiol that participates within lysosomes in a thiol-disulfide interchange reaction converting cystine into cysteine and cysteine-cysteamine mixed disulfide, both of which can exit the lysosome in patients with cystinosis.
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose may include convulsions (seizures), increased thirst and unusual tiredness or weakness.
- LD50 (rat)N/A
- LD50 (mouse)LD50=250 mg/kg(ip); LD50=450 mg/kg(intraperitoneal); LD50=625 mg/kg(peroral)