Fatty-acid amide hydrolase 1
Target information
- CovInDB Protein
- P97612
- Name
- Fatty-acid amide hydrolase 1
- Encoding Gene
- Faah
- Synonyms
-
- Anandamide amidohydrolase 1
- Oleamide hydrolase 1
- Taxonomy
- Rattus norvegicus (Rat)
- Description
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Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
- Sequence
-
MVLSEVWTTLSGVSGVCLACSLLSAAVVLRWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
- Active Site
-
Feature Key Position(s) Description Active site 142 Charge relay system Binding site 191 Substrate; via carbonyl oxygen Active site 217 Charge relay system Binding site 217 Substrate Active site 241 Acyl-ester intermediate - Structure
-
Check covalent ligand-protein complexes.
PDB: 2VYA
Show SurfaceSite View - Reference
- UniProt
Covalent Inhibitors
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