Urease subunit alpha
Target information
- CovInDB Protein
- P41020
- Name
- Urease subunit alpha
- Encoding Gene
- ureC
- Synonyms
-
- Urea amidohydrolase subunit alpha
- Taxonomy
- Sporosarcina pasteurii (Bacillus pasteurii)
- Description
-
Urease, an enzyme that catalyzes the hydrolysis of urea, forming ammonia and carbon dioxide.
- Sequence
-
MKINRQQYAESYGPTVGDQVRLADTDLWIEVEKDTTYGDEAVNFGGGKVLREGMGENGTYTRTENVLDLLLTNALILDYTGIYKADIGVKDGYIVGIGKGGNPDIMDGVTPNMIVGTATEVIAAEGKIVTAGGIDTHVHFINPDQVDVALANGITTLFGGGTGPAEGSKATTVTPGPWNIEKMLKSTEGLPINVGILGKGHGSSIAPIMEQIDAGAAGLKIHEDWGATPASIDRSLTVADEADVQVAIHSDTLNEAGFLEDTLRAINGRVIHSFHVEGAGGGHAPDIMAMAGHPNVLPSSTNPTRPFTVNTIDEHLDMLMVCHHLKQNIPEDVAFADSRIRPETIAAEDILHDLGIISMMSTDALAMGRAGEMVLRTWQTADKMKKQRGPLAEEKNGSDNFRAKRYVSKYTINPAIAQGIAHEVGSIEEGKFADLVLWEPKFFGVKADRVIKGGIIAYAQIGDPSASIPTPQPVMGRRMYGTVGDLIHDTNITFMSKSSIQQGVPAKLGLKRRIGTVKNCRNIGKKDMKWNDVTTDIDINPETYEVKVDGEVLTCEPVKELPMAQRYFLF
- Active Site
-
Feature Key Position(s) Description Metal binding 137 Nickel 1; via tele nitrogen Metal binding 139 Nickel 1; via tele nitrogen Binding site 139 Substrate Binding site 170 Substrate; via carbonyl oxygen Metal binding 220 Nickel 1; via carbamate group Metal binding 220 Nickel 2; via carbamate group Binding site 222 Substrate Metal binding 249 Nickel 2; via pros nitrogen Binding site 249 Substrate Metal binding 275 Nickel 2; via tele nitrogen Active site 323 Proton donor Metal binding 363 Nickel 1 Binding site 366 Substrate; via carbonyl oxygen - Structure
- Not Available
- Reference
- UniProt
Covalent Inhibitors
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