Proteasome subunit beta type-5
Target information
- CovInDB Protein
- P30656
- Name
- Proteasome subunit beta type-5
- Encoding Gene
- PRE2
- Synonyms
-
- Macropain subunit PRE2
- Multicatalytic endopeptidase complex subunit PRE2
- Proteasome component PRE2
- Proteinase YSCE subunit PRE2
- Taxonomy
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
- Description
-
The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib.
- Sequence
-
MQAIADSFSVPNRLVKELQYDNEQNLESDFVTGASQFQRLAPSLTVPPIASPQQFLRAHTDDSRNPDCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG
- Active Site
-
Feature Key Position(s) Description Binding site 124 Bortezomib; via amide nitrogen Active site 76 Nucleophile - Structure
-
Check covalent ligand-protein complexes.
PDB: 4NNN
Show SurfaceSite View - Reference
- UniProt
Covalent Inhibitors
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