Proteasome subunit beta type-5

Target information

CovInDB Protein
P28074
Name
Proteasome subunit beta type-5
Encoding Gene
PSMB5
Synonyms
  • Macropain epsilon chain
  • Multicatalytic endopeptidase complex epsilon chain
  • Proteasome chain 6
  • Proteasome epsilon chain
  • Proteasome subunit MB1
  • Proteasome subunit X
Taxonomy
Homo sapiens (Human)
Description

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.

Sequence

MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP

Active Site
Feature Key Position(s) Description
Binding site 108 Bortezomib; via amide nitrogen
Active site 60 Nucleophile
Structure

Check covalent ligand-protein complexes.

PDB:  5LEY

Show Surface
Site View
Reference
UniProt



Covalent Inhibitors

  Download

Structure Rank ID Warhead Reaction Mechanism Target Site Activity Type Relation Value Unit Experiment Method Assay Reference