UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
Target information
- CovInDB Protein
- P22188
- Name
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
- Encoding Gene
- murE
- Synonyms
-
- Meso-A2pm-adding enzyme
- Meso-diaminopimelate-adding enzyme
- UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase
- UDP-MurNAc-tripeptide synthetase
- UDP-N-acetylmuramyl-tripeptide synthetase
- Taxonomy
- Escherichia coli (strain K12)
- Description
-
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.
- Sequence
-
MADRNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA
- Active Site
-
Feature Key Position(s) Description Binding site 157 UDP-MurNAc-L-Ala-D-Glu Binding site 185 UDP-MurNAc-L-Ala-D-Glu Binding site 191 UDP-MurNAc-L-Ala-D-Glu Binding site 193 UDP-MurNAc-L-Ala-D-Glu Binding site 27 UDP-MurNAc-L-Ala-D-Glu; via carbonyl oxygen Binding site 29 UDP-MurNAc-L-Ala-D-Glu Binding site 390 Meso-diaminopimelate Binding site 465 Meso-diaminopimelate; via carbonyl oxygen Binding site 469 Meso-diaminopimelate - Structure
-
PDB: 1E8C
Show SurfaceSite View - Reference
- UniProt
Covalent Inhibitors
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