Fructose-1,6-bisphosphatase 1
Target information
- CovInDB Protein
- P09467
- Name
- Fructose-1,6-bisphosphatase 1
- Encoding Gene
- FBP1
- Synonyms
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- FBPase 1
- D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
- Liver FBPase
- Taxonomy
- Homo sapiens (Human)
- Description
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Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
- Sequence
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MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
- Active Site
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Feature Key Position(s) Description Metal binding 119 Magnesium 2 Metal binding 119 Magnesium 3 Metal binding 121 Magnesium 2; via carbonyl oxygen Metal binding 122 Magnesium 3 Binding site 141 AMP Binding site 265 Substrate Metal binding 281 Magnesium 3 Metal binding 69 Magnesium 1 Metal binding 98 Magnesium 1 Metal binding 98 Magnesium 2 - Structure
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Check covalent ligand-protein complexes.
PDB: 6LS5
Show SurfaceSite View - Reference
- UniProt
Covalent Inhibitors
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