Cholinesterase

Target information

CovInDB Protein
P06276
Name
Cholinesterase
Encoding Gene
BCHE
Synonyms
  • Acylcholine acylhydrolase
  • Butyrylcholine esterase
  • Choline esterase II
  • Pseudocholinesterase
Taxonomy
Homo sapiens (Human)
Description

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.

Sequence

MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL

Active Site
Feature Key Position(s) Description
Binding site 110 Tacrine; inhibitor
Active site 226 Acyl-ester intermediate
Active site 353 Charge relay system
Active site 466 Charge relay system
Binding site 466 Tacrine; via carbonyl oxygen; inhibitor
Structure

Check covalent ligand-protein complexes.

PDB:  2XQK

Show Surface
Site View
Reference
UniProt



Covalent Inhibitors

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Structure Rank ID Warhead Reaction Mechanism Target Site Activity Type Relation Value Unit Experiment Method Assay Reference