Urokinase-type plasminogen activator

Target information

CovInDB Protein
P00749
Name
Urokinase-type plasminogen activator
Encoding Gene
PLAU
Synonyms
  • Urokinase-type plasminogen activator
  • U-plasminogen activator
  • uPA
Taxonomy
Homo sapiens (Human)
Description

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

Sequence

MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL

Active Site
Feature Key Position(s) Description
Active site 224 Charge relay system
Active site 275 Charge relay system
Active site 376 Charge relay system
Structure

Check covalent ligand-protein complexes.

PDB:  5YC6

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Reference
UniProt



Covalent Inhibitors

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