VGSC-DB Target ID	NAT005
Name	Sodium channel protein type 5 subunit alpha
Synonyms	Sodium channel protein cardiac muscle subunit alpha Sodium channel protein type V subunit alpha Voltage-gated sodium channel subunit alpha Nav1.5
Description	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.
Organism	Human
PDB ID	6UZ0, 6UZ3, 6LQA, 7DTC
UniProt	Q14524

VGSC-DB ID	Sructure	PubChem CID	Molecular Formula	IC50/EC50* (nM)	Binding Site	Organism	Article DOI