- Molecular NameCephalexin
- SynonymCefalessina [DCIT]; Cefalexin; Cefalexin Sodium; Cefalexina [INN-Spanish]; Cefalexine [INN-French]; Cefalexinum [INN-Latin]; Cephalexin 1-hydrate; Cephalexin hydrate; Cephalexin monohydrate; Cephalexine; Cephalexinum; CEX
- Weight347.395
- Drugbank_IDDB00567
- ACS_NO15686-71-2
- Show 3D model
- LogP (experiment)0.65
- LogP (predicted, AB/LogP v2.0)-0.81
- pka4.5
- LogD (pH=7, predicted)-3.45
- Solubility (experiment)1.789 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.06
- LogSw (predicted, AB/LogsW2.0)11.62
- Sw (mg/ml) (predicted, ACD/Labs)0.69
- No.of HBond Donors4
- No.of HBond Acceptors7
- No.of Rotatable Bonds4
- TPSA138.03
- StatusFDA approved
- AdministrationN/A
- PharmacologyA first-generation cephalosporin antibiotic
- Absorption_value96.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability90.0
- Protein binding14.0
- Volume of distribution (VD)0.26 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- Metabollsm90% excreted unchanged
- Half life0.9 h
- ExcretionRenal
- Urinary Excretion91
- Clerance4.3 ml/min/kg
- ToxicitySymptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. The oral median lethal dose of cephalexin in rats is >5000 mg/kg.
- LD50 (rat)N/A
- LD50 (mouse)N/A