- Molecular NameNifedipine
- SynonymNA
- Weight346.339
- Drugbank_IDDB01115
- ACS_NO21829-25-4
- Show 3D model
- LogP (experiment)3.27
- LogP (predicted, AB/LogP v2.0)3.41
- pkaN/A
- LogD (pH=7, predicted)3.35
- Solubility (experiment)0.00602 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-3.77
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.06
- No.of HBond Donors1
- No.of HBond Acceptors8
- No.of Rotatable Bonds6
- TPSA113.46
- StatusFDA approved
- AdministrationN/A
- PharmacologyA dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive, although a large number of other uses have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers.
- Absorption_value90.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability50.0
- Protein binding96.0
- Volume of distribution (VD)0.78 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolically cleared by CYP3A; undergoes significant first-pass metabolism.
- Half life1.8 h
- ExcretionRenal: >50%, Biliary: 5-15%
- Urinary Excretion0
- Clerance7.0 ml/min/kg
- ToxicitySymptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness.
- LD50 (rat)LD50=1022 mg/kg
- LD50 (mouse)LD50=494 mg/kg