- Molecular NameIndomethacin
- SynonymIMN; Indometacine; Indometacyna; indomethacin; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethine; Indometicina
- Weight343.766
- Drugbank_IDDB00328
- ACS_NO53-86-1
- Show 3D model
- LogP (experiment)4.27
- LogP (predicted, AB/LogP v2.0)3.94
- pka4.5
- LogD (pH=7, predicted)1.44
- Solubility (experiment)0.00858 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.11
- LogSw (predicted, AB/LogsW2.0)0.02
- Sw (mg/ml) (predicted, ACD/Labs)0.09
- No.of HBond Donors1
- No.of HBond Acceptors5
- No.of Rotatable Bonds4
- TPSA68.53
- StatusFDA approved
- AdministrationOral, rectal, IV, topical
- PharmacologyA non-steroidal anti-inflammatory drug commonly used to reduce fever, pain, stiffness, and swelling. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms.
- Absorption_value100.0
- Absorption (description)N/A
- Caco_2-4.69
- Bioavailability100.0
- Protein binding99.0
- Volume of distribution (VD)0.29 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIndomethacin exists in the plasma as the parent drug and its desmethyl, desbenzoyl, and desmethyl-desbenzoyl metabolites produced by CYP 1A2, 2C11, 2E1, 2C9 and 2C19 all in the unconjugated form. About 60 percent of an oral dosage is recovered in urine as drug and metabolites (26 percent as indomethacin and its glucuronide formed by UGT 1A3, 1A9, 1A1 and 2B7), and 33 percent is recovered in feces (1.5 percent as indomethacin).
- Half life2.4 h
- ExcretionRenal 60%, faecal 33%
- Urinary Excretion15
- Clerance1.4 ml/min/kg
- ToxicityAdverse reactions occured with frequency more than 3% include nausea, dyspepsia, headache and dizziness.
- LD50 (rat)LD50=25
- LD50 (mouse)LD50=25