- Molecular NameEtizolam
- SynonymNA
- Weight342.854
- Drugbank_IDN/A
- ACS_NO40054-69-1
- Show 3D model
- LogP (experiment)3.1
- LogP (predicted, AB/LogP v2.0)2.74
- pkaN/A
- LogD (pH=7, predicted)2.74
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-4.53
- LogSw (predicted, AB/LogsW2.0)0.12
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors0
- No.of HBond Acceptors4
- No.of Rotatable Bonds2
- TPSA70.79
- StatusN/A
- AdministrationN/A
- PharmacologyA thienodiazepine drug which is a benzodiazepine analog. The etizolam molecule differs from most other benzodiazepines in that the benzene ring has been replaced by a thiophene ring.[1] It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
- Absorption_valueN/A
- Absorption (description)Etizolam is rapidly absorbed after oral administration
- Caco_2N/A
- BioavailabilityN/A
- Protein binding93.0
- Volume of distribution (VD)0.9 L (after a single 0.5 mg dose); usually referred to as 1.0 L/kg.
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmAlmost entirely eliminated by non-renal pathways. Peak plasma concentrations are reached within 0.5 to 2 h. There is little accumulation of the drug in the body and elimination is by biotransformation of the drug; mainly microsomal oxidation to produce hydroxylated derivatives which are subsequently conjugated. The main metabolite is α-hydroxyetizolam (20% of which is in the unconjugated form) and is pharmacologically active as opposed to the other metabolites which are not.Hepatic
- Half life3.4 h
- ExcretionRenal
- Urinary ExcretionN/A
- CleranceOral, between 10.4 and 19.3 (mean 13.8) L/h (after a single 0.5 mg dose).
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A