- Molecular NameLactulose
- SynonymNA
- Weight342.297
- Drugbank_IDDB00581
- ACS_NO4618-18-2
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)-3.77
- pkaN/A
- LogD (pH=7, predicted)-3.77
- Solubility (experiment)764 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.02
- LogSw (predicted, AB/LogsW2.0)557.36
- Sw (mg/ml) (predicted, ACD/Labs)359.08
- No.of HBond Donors8
- No.of HBond Acceptors11
- No.of Rotatable Bonds5
- TPSA189.53
- StatusFDA approved
- AdministrationN/A
- PharmacologyA synthetic sugar used in the treatment of constipation and hepatic encephalopathy, a complication of liver disease.
- Absorption_value1.0
- Absorption (description)Poorly absorbed from the gastrointestinal tract as no human enzyme that is capable of hydrolysis of this disaccharide is present in human gastrointestinal tissue.
- Caco_2N/A
- Bioavailability1.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- Metabollsm100% in colon by enteric bacteria
- Half life1.7~2 h
- ExcretionAbout 70% of the total dose is excreted unchanged in urine
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySide effects include diarrhea and resultant dehydration.
- LD50 (rat)LD50=18.2 g/kg
- LD50 (mouse)N/A