• Molecular NamePropiomazine
  • SynonymNA
  • Weight340.491
  • Drugbank_IDDB00777
  • ACS_NO362-29-8
  • Show 3D model
  • LogP (experiment)4.79
  • LogP (predicted, AB/LogP v2.0)4.7
  • pka6.6
  • LogD (pH=7, predicted)2.96
  • Solubility (experiment)0.000454 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.48
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors0
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds5
  • TPSA48.85
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antihistamine, blocking H1 receptors. It is used to treat insomnia, and to produce sleepiness or drowsiness and to relieve anxiety before or during surgery or other procedures and in combination with analgetics also during labor.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability33.0
  • Protein binding81.0
  • Volume of distribution (VD)2~3 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPropiomazine is metabolized to N-demethyl metabolite in plasma.\
  • Half life9 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityRare, serious side effects include convulsions (seizures); difficult or unusually fast breathing; fast or irregular heartbeat or pulse; fever (high); high or low blood pressure; loss of bladder control; muscle stiffness (severe); unusual increase in sweating; unusually pale skin; and unusual tiredness or weakness.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A