- Molecular NamePentamidine
- Synonym1,3-bis(4-amidinophenoxy)pentane; 4, 4'-Diamidinodiphenoxypentane; Pentamide; Pentamidine Isethionate; PNT
- Weight340.427
- Drugbank_IDDB00738
- ACS_NO100-33-4
- Show 3D model
- LogP (experiment)2.8
- LogP (predicted, AB/LogP v2.0)2.35
- pkaN/A
- LogD (pH=7, predicted)-2.65
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-0.83
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)16.6
- No.of HBond Donors6
- No.of HBond Acceptors6
- No.of Rotatable Bonds10
- TPSA118.2
- StatusFDA approved
- AdministrationIV, IM, inhalation
- PharmacologyAn antimicrobial medication given for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii), a severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma brucei gambiense (West African Trypanosomiasis).
- Absorption_value0.0
- Absorption (description)Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.
- Caco_2N/A
- Bioavailability0.0
- Protein binding69.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic
- Half life9.1~13.2 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.
- LD50 (rat)N/A
- LD50 (mouse)N/A