• Molecular NamePropoxyphene
  • SynonymD-Propoxyphene; Dextropropoxyphene; Dextropropoxyphene-M; Dextroproxifeno; Propoxyphene HCl
  • Weight339.479
  • Drugbank_IDDB00647
  • ACS_NO469-62-5
  • Show 3D model
  • LogP (experiment)4.2
  • LogP (predicted, AB/LogP v2.0)4.54
  • pka6.3
  • LogD (pH=7, predicted)3.28
  • Solubility (experiment)0.0196 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.27
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.02
  • No.of HBond Donors0
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds9
  • TPSA29.54
  • StatusFDA approved
  • AdministrationOral, IV, rectal.
  • PharmacologyAn analgesic in the opioid category. It is used to treat mild pain and is additionally an anti-tussive and local anesthetic.
  • Absorption_value95.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability30.0
  • Protein binding75.0
  • Volume of distribution (VD)16 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half lifedextropropoxyphene 8 to 24 h (mean 15), norpropoxyphene 20 to 50 h (mean 29).
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityComa, respiratory depression, circulatory collapse, and pulmonary edema. Seizures occur more frequently in patients with propoxyphene intoxication than in those with opiate intoxication. LD50=230mg/kg (orally in rat, Emerson)
  • LD50 (rat)LD50=230 mg/kg
  • LD50 (mouse)N/A