• Molecular NameNalmefene
  • SynonymNA
  • Weight339.435
  • Drugbank_IDN/A
  • ACS_NO55096-26-9
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)2.96
  • pka7.63
  • LogD (pH=7, predicted)1.41
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.45
  • LogSw (predicted, AB/LogsW2.0)0.07
  • Sw (mg/ml) (predicted, ACD/Labs)0.22
  • No.of HBond Donors2
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds2
  • TPSA52.93
  • StatusN/A
  • AdministrationOral, Intravenous
  • PharmacologyAn opioid receptor antagonist used primarily in the management of alcohol dependence, and also has been investigated for the treatment of other addictions such as pathological gambling and addiction to shopping.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability40.0
  • Protein binding34.4
  • Volume of distribution (VD)8.0 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolized primarily by UGT.
  • Half lifeOral: 11 h, intravenous: 8 to 9 h.
  • ExcretionN/A
  • Urinary Excretion9.6
  • Clerance15 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A