• Molecular NamePafenolol
  • SynonymNA
  • Weight337.464
  • Drugbank_IDN/A
  • ACS_NO75949-61-0
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)1.74
  • pka9.18
  • LogD (pH=7, predicted)-0.67
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.26
  • LogSw (predicted, AB/LogsW2.0)6.65
  • Sw (mg/ml) (predicted, ACD/Labs)0.02
  • No.of HBond Donors4
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds10
  • TPSA82.62
  • StatusN/A
  • AdministrationN/A
  • PharmacologyPafenolol had been used in the treatment of essential hypertension
  • Absorption_value29.0
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolized probably by a hepatic route. Undergoes a low biotransformation (about 10%) in men. The only evaluated metabolite is alpha-OH pafenolol.
  • Half life3.1 h for IV dose, 6.7 h for the oral dose
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A