- Molecular NameFentanyl
- SynonymFentanila [INN-Spanish]; fentanyl; Fentanyl citrate; Fentanylum [INN-Latin]
- Weight336.479
- Drugbank_IDDB00813
- ACS_NO437-38-7
- Show 2D model
- LogP (experiment)4.05
- LogP (predicted, AB/LogP v2.0)4.2
- pka7.3, and 8.4
- LogD (pH=7, predicted)3.09
- Solubility (experiment)0.2 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.96
- LogSw (predicted, AB/LogsW2.0)0.13
- Sw (mg/ml) (predicted, ACD/Labs)0.14
- No.of HBond Donors0
- No.of HBond Acceptors3
- No.of Rotatable Bonds6
- TPSA23.55
- StatusFDA approved
- AdministrationN/A
- PharmacologyA synthetic primary μ-opioid agonist commonly used to treat chronic breakthrough pain and is commonly used in pre-procedures.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability1.0
- Protein binding84.0
- Volume of distribution (VD)4 L/kg
- Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, 1.0.
- MetabollsmRapidly metabolised by by CYP3A in the liver. Two metabolites, norfentanyl and despropionylfentanyl, have been detected in plasma at concentrations similar to those of fentanyl.
- Half life3.7 h (dose-dependent; also increased in the elderly and premature infants and during cardiopulmonary by-pass surgery).
- ExcretionAbout 70% of a dose is excreted in the urine in 72 h, mostly as metabolites, with about 10 to 20% of a dose being excreted as unchanged drug in 48 h. About 9% of a dose is eliminated in the faeces. It crosses the placenta and small amounts may be found in breast milk.
- Urinary Excretion8
- Clerance13 ml/min/kg.
- ToxicityThe estimated minimum lethal dose is 2 mg.
- LD50 (rat)N/A
- LD50 (mouse)N/A