- Molecular NameDicoumarol
- SynonymBHC; Bis-Hydroxycoumarin; Bishydroxycoumarin; Dicoumarin; Dicoumarol
- Weight336.299
- Drugbank_IDDB00266
- ACS_NO66-76-2
- Show 2D model
- LogP (experiment)2.07
- LogP (predicted, AB/LogP v2.0)1.4
- pka4.4, 8.0
- LogD (pH=7, predicted)-0.59
- Solubility (experiment)0.128 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.62
- LogSw (predicted, AB/LogsW2.0)0.07
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors2
- No.of HBond Acceptors6
- No.of Rotatable Bonds2
- TPSA93.06
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn anticoagulant that functions as a Vitamin K antagonist (similar to warfarin). It is also used in biochemical experiments as an inhibitor of reductases. Dicoumarol is a chemical substance of plant origin, a derivative of coumarin.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein binding99.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- Metabollsmplasmatic proteins
- Half lifedose-dependent and may range from 7~100 h
- Excretionfaeces, urine
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)LD50=250 mg/kg
- LD50 (mouse)LD50=233 mg/kg