- Molecular NameLormetazepam
- SynonymNA
- Weight335.19
- Drugbank_IDN/A
- ACS_NO848-75-9
- Show 3D model
- LogP (experiment)2.5
- LogP (predicted, AB/LogP v2.0)2.57
- pkaN/A
- LogD (pH=7, predicted)2.57
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-3.62
- LogSw (predicted, AB/LogsW2.0)0.02
- Sw (mg/ml) (predicted, ACD/Labs)0.08
- No.of HBond Donors1
- No.of HBond Acceptors4
- No.of Rotatable Bonds1
- TPSA52.9
- StatusN/A
- AdministrationN/A
- PharmacologyA drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
- Absorption_value100.0
- Absorption (description)Well absorbed after oral administration.
- Caco_2N/A
- Bioavailability75.0
- Protein binding90.0
- Volume of distribution (VD)5 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolised to some extent by N-demethylation to lorazepam.
- Half lifelormetazepam about 10 h, appears to be increased in elderly subjects; lormetazepam glucuronide about 13 h.
- ExcretionAbout 80% of a dose is excreted in the urine as lormetazepam glucuronide in 72 h, and about 6% as lorazepam glucuronide.
- Urinary ExcretionN/A
- Clerance4 ml/min/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A