• Molecular NameMitomycin
  • Synonym7-Amino-9α-methoxymitosane; Mitamycin; MMC
  • Weight334.332
  • Drugbank_IDDB00305
  • ACS_NO50-07-7
  • Show 3D model
  • LogP (experiment)-0.4
  • LogP (predicted, AB/LogP v2.0)-0.52
  • pka10.9
  • LogD (pH=7, predicted)-0.53
  • Solubility (experiment)8.43 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.71
  • LogSw (predicted, AB/LogsW2.0)0.34
  • Sw (mg/ml) (predicted, ACD/Labs)0.64
  • No.of HBond Donors5
  • No.of HBond Acceptors9
  • No.of Rotatable Bonds4
  • TPSA158.92
  • StatusFDA approved
  • AdministrationIntravenous therapy
  • PharmacologyA drug is used to treat upper gastro-intestinal (e.g. esophageal carcinoma) and breast cancers, as well as by bladder instillation for superficial bladder tumours.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life8~48 min
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include nausea and vomiting.
  • LD50 (rat)LD50=30 mg/kg
  • LD50 (mouse)LD50=23 mg/kg