• Molecular NamePenicillin_G
  • SynonymNA
  • Weight333.388
  • Drugbank_IDDB01053
  • ACS_NO61-33-6
  • Show 3D model
  • LogP (experiment)1.83
  • LogP (predicted, AB/LogP v2.0)2.08
  • pka2.8
  • LogD (pH=7, predicted)-1.88
  • Solubility (experiment)0.21 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)0.48
  • LogSw (predicted, AB/LogsW2.0)1.02
  • Sw (mg/ml) (predicted, ACD/Labs)0.82
  • No.of HBond Donors2
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds4
  • TPSA112.01
  • StatusFDA approved
  • Administrationintravenous bolus
  • PharmacologyPenicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding60.0
  • Volume of distribution (VD)0.6 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life0.5 h
  • Excretionrenal
  • Urinary Excretion79
  • Clerance5~9 ml/min/kg
  • ToxicityNeurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams.
  • LD50 (rat)8900 mk/kg
  • LD50 (mouse)N/A