• Molecular NameAlfaxalone
  • Synonymalphaxalone; alphaxolone
  • Weight332.484
  • Drugbank_IDN/A
  • ACS_NO23930-19-0
  • Show 3D model
  • LogP (experiment)3.28
  • LogP (predicted, AB/LogP v2.0)3.25
  • pkaN/A
  • LogD (pH=7, predicted)3.25
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-3.91
  • LogSw (predicted, AB/LogsW2.0)0.04
  • Sw (mg/ml) (predicted, ACD/Labs)0.04
  • No.of HBond Donors1
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds1
  • TPSA54.37
  • StatusN/A
  • AdministrationInjection
  • PharmacologyA neurosteroid general anaesthetic.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding35.0
  • Volume of distribution (VD)0.8 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIt undergoes almost 100% first-pass metabolism by reduction of the 20-oxo group and conjugation with glucuronic acid
  • Half life0.5 h
  • ExcretionAbout 60% of a dose is excreted in the urine in 24 h and 80% in 5 days.
  • Urinary ExcretionN/A
  • ClerancePlasma clearance, about 20 mL/min/kg.
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A