• Molecular NameCiprofloxacin
  • Synonymciprofloxacin; Ciprofloxacin dihydrochloride; Ciprofloxacin HCl; Ciprofloxacin hydrochloride; Ciprofloxacin monohydrochloride; Ciprofloxacina
  • Weight331.347
  • Drugbank_IDDB00537
  • ACS_NO85721-33-1
  • Show 3D model
  • LogP (experiment)-1.08
  • LogP (predicted, AB/LogP v2.0)2.18
  • pka6.09
  • LogD (pH=7, predicted)1.05
  • Solubility (experiment)0.0892 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.43
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors1
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds3
  • TPSA73.74
  • StatusFDA approved
  • AdministrationOral, intravenous, topical (ear drops, eye drops)
  • PharmacologyA drug used to treat bacterial infections. It is a second generation fluoroquinolone antibacterial. It kills bacteria by interfering with the enzymes that cause DNA to rewind after being copied, which stops DNA and protein synthesis.
  • Absorption_value69.0
  • Absorption (description)Rapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.
  • Caco_2N/A
  • Bioavailability60.0
  • Protein binding30.0
  • Volume of distribution (VD)2.2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic, including CYP1A2
  • Half life3.3 h
  • ExcretionThe drug is eliminated principally by urinary excretion (active tubular secretion as well as glomerular filtration). Non-renal clearance may account for about a third of elimination (hepatic metabolism, biliary excretion, and possibly transluminal secretion across intestinal mucosa). Active metabolites have been identified. About 40 to 50% of an oral dose is excreted unchanged in urine with about 15% excreted as metabolites. Up to 70% of a parenteral dose may be excreted unchanged within 24 h and 10% as metabolites. Faecal excretion over 5 days has accounted for 20 to 35% of an oral dose and 15% of an intravenous dose. Only small amounts are removed by haemodialysis or peritoneal dialysis.
  • Urinary Excretion50
  • Clerance7.6 ml/min/kg
  • ToxicityThe major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics.
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=273 (intravenous administration); LD50=5000 (oral administration)