• Molecular NameHydroflumethiazide
  • SynonymDihydroflumethazide; Hidroflumetiazid; Hydroflumethazide; Hydroflumethizide; Trifluoromethylhydrazide; Trifluoromethylhydrothiazide
  • Weight331.295
  • Drugbank_IDDB00774
  • ACS_NO135-09-1
  • Show 2D model
  • LogP (experiment)0.36
  • LogP (predicted, AB/LogP v2.0)0.52
  • pka8.5, 10.0
  • LogD (pH=7, predicted)0.51
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.38
  • LogSw (predicted, AB/LogsW2.0)0.59
  • Sw (mg/ml) (predicted, ACD/Labs)1.36
  • No.of HBond Donors4
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds2
  • TPSA135.12
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA diuretic.
  • Absorption_value67.0
  • Absorption (description)Incompletely but fairly rapidly absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability50.0
  • Protein binding75.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, about 0.7.
  • MetabollsmN/A
  • Half lifeDerived from urinary excretion data, 5~18 h (dose-dependent).
  • ExcretionDuring daily dosing, 50 to 70% of a dose is excreted in the 24-h urine as unchanged drug and about 2% as 2,4-disulfamyl-5-trifluoromethylaniline (DTA).
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A