- Molecular NameMalathion
- SynonymCarbofos; Carbophos; Compound 4049; Experimental insecticide 4049; Insecticide no; 4049; malathion; Malathione; Maldison; Mercaptosuccinic acid diethyl ester; Mercaptothion; Mercaptotion; MLT; Oleophosphothion
- Weight330.362
- Drugbank_IDDB00772
- ACS_NO121-75-5
- Show 3D model
- LogP (experiment)2.36
- LogP (predicted, AB/LogP v2.0)2.64
- pkaN/A
- LogD (pH=7, predicted)2.64
- Solubility (experiment)0.143 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-3.25
- LogSw (predicted, AB/LogsW2.0)0.7
- Sw (mg/ml) (predicted, ACD/Labs)0.19
- No.of HBond Donors0
- No.of HBond Acceptors6
- No.of Rotatable Bonds11
- TPSA138.26
- StatusFDA approved
- AdministrationOcutaneous
- PharmacologyAn organophosphate parasympathomimetic which binds irreversibly to cholinesterase. Malathion is an insecticide of relatively low human toxicity.
- Absorption_valueN/A
- Absorption (description)Absorbed after oral ingestion but absorbed only slowly and to a small extent through intact skin.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is metabolised by conversion to malaoxon, the toxic keto analogue, and by hydrolysis to malathion α-mono- and dicarboxylic acids which are the major metabolites. Other hydrolysis products include dimethylthiophosphoric acid (DMTP) and dimethyldithiophosphoric acid (DMDTP) which have been detected in the urine of subjects exposed to malathion.
- Half lifeDerived from urinary excretion data, 3 h
- ExcretionAfter ingestion, up to 25% is excreted in the 24 h urine as ether-extractable phosphates, mostly in the first 8 h.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityMalathion is less toxic than most other organophosphorus pesticides; the estimated minimum lethal dose is 25 g; the maximum permissible atmospheric concentration is 10 mg/m3 and the maximum acceptable daily intake is 20 μg/kg.
- LD50 (rat)LD50=1000~10,000 mg/kg
- LD50 (mouse)LD50=2800