• Molecular NameParoxetine
  • SynonymParoxetina [INN-Spanish]; paroxetine; Paroxetine Hcl; Paroxetinum [INN-Latin]
  • Weight329.371
  • Drugbank_IDDB00715
  • ACS_NO61869-08-7
  • Show 2D model
  • LogP (experiment)3.369
  • LogP (predicted, AB/LogP v2.0)2.98
  • pka9.51
  • LogD (pH=7, predicted)0.4
  • Solubility (experiment)5.4 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.03
  • LogSw (predicted, AB/LogsW2.0)0.1
  • Sw (mg/ml) (predicted, ACD/Labs)0.02
  • No.of HBond Donors1
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds4
  • TPSA39.72
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA selective serotonin reuptake inhibitor (SSRI) antidepressant.
  • Absorption_value100.0
  • Absorption (description)Completely absorbed from GI,
  • Caco_2N/A
  • Bioavailability50.0
  • Protein binding95.0
  • Volume of distribution (VD)17.2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolized by CYP2D6 (polymorphic); undergoes time- and dose-dependent autoinhibition of metabolic CL in extensive metabolizers.
  • Half life17 h
  • Excretion64% in urine, 36% in bile
  • Urinary Excretion<2
  • Clerance8.6 ml/min/kg
  • ToxicityComa, dizziness, drowsiness, facial flushing, nausea, sweating, tremor, vomiting
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=500mg/kg