• Molecular NameNitisinone
  • Synonymnitisinone
  • Weight329.23
  • Drugbank_IDDB00348
  • ACS_NO104206-65-7
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.3
  • pkaN/A
  • LogD (pH=7, predicted)-0.58
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.1
  • LogSw (predicted, AB/LogsW2.0)0.02
  • Sw (mg/ml) (predicted, ACD/Labs)0.23
  • No.of HBond Donors0
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds4
  • TPSA100.04
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA drug originally developed as an herbicide now used in the treatment of hereditary tyrosinemia type 1.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability90.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life54 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySide effects include elevated plasma levels of this amino acid, hepatic and liver failure.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A