- Molecular NameDocosanol
- SynonymBehenyl alcohol; docosanol
- Weight326.609
- Drugbank_IDDB00632
- ACS_NO661-19-8
- Show 3D model
- LogP (experiment)9.017
- LogP (predicted, AB/LogP v2.0)9.33
- pkaN/A
- LogD (pH=7, predicted)9.33
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-11.83
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors1
- No.of HBond Acceptors1
- No.of Rotatable Bonds20
- TPSA20.23
- StatusFDA approved
- AdministrationTopical
- PharmacologyA saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement (as an individual entity and also as a constituent of polyicosanol), and more recently, in an FDA-approved pharmaceutical, Abreva[5], approved for reducing the duration of "cold sores" caused by the herpes simplex virus (see antiviral agent).
- Absorption_valueN/A
- Absorption (description)Topical absorption has been shown to be minimal under conditions reflecting normal clinical use.
- Caco_2N/A
- Bioavailability0.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.
- LD50 (rat)N/A
- LD50 (mouse)N/A