- Molecular NameAcepromazine
- Synonym10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone; 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone; Acetylpromazine; ACP
- Weight326.464
- Drugbank_IDDB01614
- ACS_NO61-00-7
- Show 3D model
- LogP (experiment)2.3
- LogP (predicted, AB/LogP v2.0)4.39
- pka9.3
- LogD (pH=7, predicted)2.26
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.66
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors0
- No.of HBond Acceptors3
- No.of Rotatable Bonds5
- TPSA48.85
- StatusFDA approved
- AdministrationIV, IM, oral
- PharmacologyA phenothiazine derivative antipsychotic drug.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability55.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmAcepromazine is converted to 2-(1-hydroxyethyl)promazine, by red blood cells, and 2-(1-hydroxyethyl)promazine which may be the major unconjugated metabolite of acepromazine in humans.
- Half lifeN/A
- ExcretionFound in equine urine up to 96 hours after dosage
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityA 43-year-old woman was found dead where acepromazine was found in chest-cavity blood, the liver, brain and bile at concentrations of 0.6, 3.0, 0.4, and 6.5 mg/L, respectively. The stomach contents contained a total of 2.5 mg acepromazine. [L. I. Stowell,J. Anal. Toxicol.,1998, 22(2), 166–168]. A 28-year-old woman was found dead and toxicological analysis showed a blood concentration of 2.4 mg/L acepromazine and 3.29 mg/L zolpidem, urine concentration of 0.37 mg/L and 2.54 mg/L, respectively, and gastric contents concentration of 20.05 mg/L and 34.27 mg/L, respectively. [A. Tracqui et al.,Am. J. Forensic Med. Pathol.,1993, 14(4), 309–312].
- LD50 (rat)N/A
- LD50 (mouse)N/A