• Molecular NameAmdinocillin
  • SynonymAmdinocillin mecillinam; Mecillinam
  • Weight325.433
  • Drugbank_IDDB01163
  • ACS_NO32887-01-7
  • Show 2D model
  • LogP (experiment)2.33
  • LogP (predicted, AB/LogP v2.0)2.09
  • pkaN/A
  • LogD (pH=7, predicted)-0.42
  • Solubility (experiment)Soluble
  • LogS (predicted, ACD/Labs)(ph=7)-2.89
  • LogSw (predicted, AB/LogsW2.0)1.38
  • Sw (mg/ml) (predicted, ACD/Labs)0.4
  • No.of HBond Donors1
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds3
  • TPSA98.51
  • StatusFDA approved
  • AdministrationIntravenous, intramuscular
  • PharmacologyAn extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2),[2] and is only considered to be active against Gram-negative bacteria. It is used primarily in the treatment of urinary tract infections, and has also been used to treat typhoid and paratyphoid fever.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability5.0
  • Protein binding7.5
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmSome hepatic metabolism
  • Half life1~3 h
  • ExcretionRenal and biliary, mostly unchanged
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A