• Molecular NameCitalopram
  • SynonymCitalopram Hydrobromide; Citalopramum [INN-Latin]
  • Weight324.399
  • Drugbank_IDDB00215
  • ACS_NO59729-33-8
  • Show 2D model
  • LogP (experiment)3.41
  • LogP (predicted, AB/LogP v2.0)3.89
  • pka9.5
  • LogD (pH=7, predicted)1.61
  • Solubility (experiment)0.031 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.61
  • LogSw (predicted, AB/LogsW2.0)0.06
  • Sw (mg/ml) (predicted, ACD/Labs)0.05
  • No.of HBond Donors0
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds6
  • TPSA36.26
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antidepressant drug used to treat major depression associated with mood disorders. It is also used on occasion in the treatment of body dysmorphic disorder and anxiety.
  • Absorption_value100.0
  • Absorption (description)Citalopram is readily absorbed after oral administration with a bioavailability of about 80%
  • Caco_2N/A
  • Bioavailability80.0
  • Protein binding50.0
  • Volume of distribution (VD)12.3 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (CYP3A4 & CYP2C19). The metabolites have some pharmacological activity although they do not contribute to the overall antidepressant effect of citalopram. Unlike some other selective serotonin reuptake inhibitors, it has only a mild inhibitory effect on CYP2D6.
  • Half life33 h (parent drug); desmethylcitalopram, 48 h; didesmethylcitalopram, 96 h; in the elderly, 3.75 days.
  • ExcretionAbout 12% of the daily dose is excreted unchanged in urine and an equal amount as the main active metabolite, desmethylcitalopram. Also present are an amino metabolite and a conjugated propionic acid derivative. Approximately 65% of a dose is unaccounted for and could possibly be present in faeces or undergo a number of different metabolic pathways.
  • Urinary Excretion10.5
  • Clerance4.3 ml/min/kg
  • ToxicityThe lethal concentration is 500 μg/L. Citalopram plasma concentrations were six times greater than the therapeutic concentrations in a patient who attempted suicide. There were no significant changes in unconsciousness, electrocardiogram or blood pressure. [O. L. Pedersen et al.,Psychopharmacology (Berl.).,1982, 77, 199–204].
  • LD50 (rat)N/A
  • LD50 (mouse)N/A