- Molecular NameLysergide
- Synonym(+)-LSD; (+)-lysergic acid diethylamide; 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide; Acid; Barrels; Bart simpson; Bartman; Beast; Big f; Blotter acid; Blue acid; Blue cheer; Blue mist; Blue star; Brown dots; California sunshine; Cherry top; Chief; Chocolate chips; Clearlight; Coffeinum; Contact lens; Cubes; Cupcakes; D-LSD; D-LSD-25; D-lysergic acid dethylamide; D-lysergic acid diethylamide; D-lysergic acid n,n-diethylamide; Delysid; Dextrolysergic acid diethylamide; Diethylamid kyseliny lysergove [czech]; Domes; Ergine; Fifty; Flats; Frogs; Gelatin chips; Greenies; Heavenly blue; LSD; LSD-25; Lucy in the sky with diamonds; Lysergamid; Lysergamide; Lysergaure diethylamid; Lysergic acid amide; Lysergic acid diethylamide-25; Lysergic Acid Diethylamide; Lysergidum [inn-latin]; Mean green; Mellow yellow; Microdots; n,n-diethyl-(+)-lysergamide; N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide; N,n-diethyl-d-lysergamide; N,n-diethyllysergamide; Orange mushroom; Orange sunshine; Orange wedges; Owsley; Paper acid; Pearly gates; Purple haze; Purple microdot; Royal blue; Scapes; Spoonies; Strawberry fields; Sugar; Sugar lump; Sunshine; TABS; The hawk; TMA; Trippers; Ubergluben; Wedding bells; Wedges; White light; Window pane; Yellows; ZEN
- Weight323.44
- Drugbank_IDN/A
- ACS_NO50-37-3
- Show 2D model
- LogP (experiment)2.95
- LogP (predicted, AB/LogP v2.0)3.02
- pka7.5
- LogD (pH=7, predicted)2.77
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.28
- LogSw (predicted, AB/LogsW2.0)0.12
- Sw (mg/ml) (predicted, ACD/Labs)0.44
- No.of HBond Donors1
- No.of HBond Acceptors4
- No.of Rotatable Bonds3
- TPSA39.34
- StatusN/A
- AdministrationN/A
- PharmacologyN/A
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding90.0
- Volume of distribution (VD)0.3 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is believed to undergo extensive biotransformation in the liver (hydroxylation and glucuronide conjugation) to inactive metabolites.
- Half life2.5 h
- ExcretionAbout 1% of a dose is excreted unchanged in the urine in 24 h. 2-Oxylysergide is a major metabolite although 13-hydroxy- and 14-hydroxylysergide also appear. As little as 0.5 to 1.5 μg/kg body weight is known to produce hallucinations. LSD is thought to produce its effects by binding to and activating the 5-hydroxytryptamine subtype 2 (5-HT2) receptor.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityHallucinatory effects are produced with doses of 200 to 400 μg but recovery has occurred after much larger doses (up to 10 mg). Plasma concentrations greater than 1 μg/L have been associated with toxic effects.
- LD50 (rat)N/A
- LD50 (mouse)N/A