- Molecular NameHydroxychloroquine
- Synonym2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol; Gen-Hydroxychloroquine 200mg Tablets; HCQ; Hidroxicloroquina [inn-spanish]; Hydroxychloroguine; Hydroxychloroquine sulfate; Hydroxychloroquinum [inn-latin]; Idrossiclorochina [dcit]; Oxichlorochinum; Oxichloroquine; Oxychlorochin; Oxychloroquine
- Weight321.852
- Drugbank_IDDB01611
- ACS_NO118-42-3
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)3.18
- pkaN/A
- LogD (pH=7, predicted)-0.31
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-1.74
- LogSw (predicted, AB/LogsW2.0)0.42
- Sw (mg/ml) (predicted, ACD/Labs)0.11
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds8
- TPSA48.39
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn antimalarial drug
- Absorption_value90.0
- Absorption (description)Rapidly and almost completely absorbed after oral administration.
- Caco_2N/A
- Bioavailability74.0
- Protein binding55.0
- Volume of distribution (VD)Hydroxychloroquine undergoes hepatic biotransformation to its active de-ethylated metabolites.
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life3 days
- ExcretionAbout 6% of a single dose is excreted in the urine over a period of 10 days and about 25% of a dose is eliminated in the faeces in 3 days as unchanged drug plus the de-ethylated metabolites. During daily therapy, less than 13% of a dose is excreted in the 24-h urine with 8% of the dose as unchanged drug, 2% as desethylchloroquine, 2% as desethylhydroxychloroquine, and 0.5% as didesethylchloroquine.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityIn a fatality due to the ingestion of at least 12 g, the following postmortem tissue concentrations of hydroxychloroquine were reported: blood 48 mg/L, heart blood 61 mg/L, liver 71 μg/g, urine 970 mg/L. [R. A. Dalley and D. Hainsworth,J. Forensic Sci. Soc.,1965, 5, 99–101.]
- LD50 (rat)N/A
- LD50 (mouse)LD50=2340