- Molecular NameMycophenolic acid
- SynonymMycophenoic acid
- Weight320.341
- Drugbank_IDDB01024
- ACS_NO24280-93-1
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)3.32
- pkaN/A
- LogD (pH=7, predicted)1.17
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-0.93
- LogSw (predicted, AB/LogsW2.0)0.09
- Sw (mg/ml) (predicted, ACD/Labs)0.23
- No.of HBond Donors2
- No.of HBond Acceptors6
- No.of Rotatable Bonds6
- TPSA93.06
- StatusFDA approved
- AdministrationOral, IV
- PharmacologyAn immunosuppressant drug used to prevent rejection in organ transplantation.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability82.5
- Protein binding98.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMycophenolic acid (MPA) is metabolized principally by glucuronyl transferase to glucuronidated metabolites. The phenolic glucuronide of MPA, mycophenolic acid glucuronide (MPAG), is the predominant metabolite of MPA and does not manifest pharmacological activity. The acyl glucuronide is a minor metabolite and has comparable pharmacological activity to MPA.
- Half life16.6 h
- ExcretionRenal 93%
- Urinary ExcretionN/A
- Clerance2.5 ml/min/kg
- ToxicityPossible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.
- LD50 (rat)LD50=352 mg/kg
- LD50 (mouse)LD50=1000 mg/kg