- Molecular NameEtodolac
- Synonymetodolac
- Weight319.357
- Drugbank_IDDB00749
- ACS_NO41340-25-4
- Show 3D model
- LogP (experiment)3.81
- LogP (predicted, AB/LogP v2.0)2.46
- pka4.6
- LogD (pH=7, predicted)-1.77
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)0.5
- LogSw (predicted, AB/LogsW2.0)0.35
- Sw (mg/ml) (predicted, ACD/Labs)0.53
- No.of HBond Donors3
- No.of HBond Acceptors6
- No.of Rotatable Bonds5
- TPSA95.86
- StatusFDA approved
- AdministrationN/A
- PharmacologyA class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin, Advil, Nuprin, etc.), naproxen (Aleve, Naprosyn), indomethacin (Indocin), nabumetone (Relafen) and numerous others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.
- Absorption_value70.0
- Absorption (description)Etodolac is well absorbed after oral administration
- Caco_2N/A
- Bioavailability90.0
- Protein binding99.0
- Volume of distribution (VD)0.3 to 0.5 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmExtensively metabolised in the liver, via hydroxylation followed by conjugation and acyl glucuronidation.
- Half life7 h
- ExcretionEtodolac is primarily excreted in urine but also in faeces. 1% of a dose is detected unchanged in urine with hydroxylated etodolac (46%), glucuronidated etodolac (13%), hydroxylated metabolites (5%), hydroxylated glucuronide metabolites (20%) and 4-ureidoetodolac metabolite.
- Urinary ExcretionN/A
- Clerance43.5 ml/h/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A