• Molecular NameButenafine
  • SynonymButenafina [INN-Spanish]; Butenafine [INN]; Butenafine HCL; Butenafine hydrochloride; Butenafinum [INN-Latin]…
  • Weight317.476
  • Drugbank_IDDB01091
  • ACS_NO101828-21-1
  • Show 2D model
  • LogP (experiment)7.12
  • LogP (predicted, AB/LogP v2.0)6.2
  • pkaN/A
  • LogD (pH=7, predicted)5.72
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.66
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors0
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds5
  • TPSA3.24
  • StatusFDA approved
  • Administrationtopical
  • PharmacologyA synthetic benzylamine antifungal, marketed under the trade names Mentax, Butop (India) and is the active ingredient in Schering-Plough's Lotrimin Ultra.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHeptatic. The primary metabolite in urine was formed through hydroxylation at the terminal t-butyl side-chain.
  • Half life35~100 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A