- Molecular NameZimeldine
- Synonym(Z)-3-(4'-Bromophenyl)-3-(3''-pyridyl)dimethylallylamine; (Z)-3-[1-(p-Bromophenyl)-3-(dimethylamino)propenyl]pyridine; (z)-zimelidine; Cis-zimelidine; Zimeldine
- Weight317.23
- Drugbank_IDN/A
- ACS_NO56775-88-3
- Show 3D model
- LogP (experiment)3.18
- LogP (predicted, AB/LogP v2.0)3.43
- pka3.8, 8.6
- LogD (pH=7, predicted)1.6
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.2
- LogSw (predicted, AB/LogsW2.0)0.08
- Sw (mg/ml) (predicted, ACD/Labs)0.23
- No.of HBond Donors0
- No.of HBond Acceptors2
- No.of Rotatable Bonds4
- TPSA16.13
- StatusN/A
- AdministrationN/A
- PharmacologyThe first selective serotonin reuptake inhibitor (SSRI) antidepressant to be marketed. It is a pyridylallylamine, and is structurally different from other antidepressants.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability29.0
- Protein binding90.0
- Volume of distribution (VD)Zimeldine, about 4 L/kg, norzimeldine, about 9 L/kg.
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life4~9 h (zimeldine); 15~25 h (norzimeldine)
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A