- Molecular NameClomipramine
- SynonymNA
- Weight314.86
- Drugbank_IDDB01242
- ACS_NO303-49-1
- Show 3D model
- LogP (experiment)5.19
- LogP (predicted, AB/LogP v2.0)5.3
- pka9.38
- LogD (pH=7, predicted)3.17
- Solubility (experiment)0.000294 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.98
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors0
- No.of HBond Acceptors2
- No.of Rotatable Bonds4
- TPSA6.48
- StatusFDA approved
- AdministrationN/A
- PharmacologyA psychoactive/psychiatric drug used as an antidepressant and anxiolytic agent.
- Absorption_value95.0
- Absorption (description)Rapidly and completely absorbed after oral administration
- Caco_2N/A
- Bioavailability51.0
- Protein binding92.5
- Volume of distribution (VD)20
- Blood/Plasma Partitioning ratio (D_blood)Plasma : whole blood ratio, 1.2.
- MetabollsmUndergoes extensive first-pass N-demethylation to the major active metabolite, monodesmethylclomipramine. Clomipramine and monodesmethylclomipramine are further metabolised by 8-hydroxylation, N-oxidation, and conjugation.
- Half life36 h
- ExcretionAbout 10 to 15% of a dose is excreted in the urine in 24 h, of which less than 0.2% is unchanged clomipramine or monodesmethylclomipramine. A total of 45 to 60% of a dose is excreted in the urine over a period of 14 days and about 20 to 30% is slowly eliminated in the faeces.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityToxic effects have been associated with blood concentrations greater than 0.4 mg/L of clomipramine plus monodesmethylclomipramine.
- LD50 (rat)N/A
- LD50 (mouse)LD50=354 (peroral); LD50=477 (intraperitonial); LD50=142 (intravenous); LD50=1790 (oral)