• Molecular NamePergolide
  • SynonymPergolida [INN-Spanish]; Pergolide Mesylate; Pergolide Methanesulfonate; Pergolidum [INN-Latin]
  • Weight314.497
  • Drugbank_IDDB01186
  • ACS_NO66104-22-1
  • Show 3D model
  • LogP (experiment)4.02
  • LogP (predicted, AB/LogP v2.0)4.53
  • pka7.8
  • LogD (pH=7, predicted)3.32
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.27
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.04
  • No.of HBond Donors1
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds4
  • TPSA44.33
  • StatusFDA approved; US withdrawn
  • AdministrationN/A
  • PharmacologyAn ergoline-based dopamine receptor agonist used for the treatment of Parkinson's disease.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability38.0
  • Protein binding90.0
  • Volume of distribution (VD)17~32 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmExtensively hepatic
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)LD50=15 mg/kg
  • LD50 (mouse)N/A